Implementing an antibiotic cycle program to reduce antimicrobial resistance while optimizing antibiotic usage: a sobering experience from a tertiary care facility in northern Mumbai

Background: The increase of antimicrobial resistance and the scarcity new broad-spectrum antibiotics is a major challenge. Antibiotic cycling one tactic that increases antibiotic homogeneity to greatest extent possible can aid in controlling pattern, but this approach has not undergone thorough evaluation. study’s objective was examine effects an strategy on susceptibility profile by avoiding alternately using beta lactam/beta lactamase inhibitors over period many years. Methods: During four-year trial period, from January 2018 December 2021, protocol applied for indoor patients. Piperacillin/tazobactam cefoperazone/sulbactam were rotated withheld full year. Using hospital’s antibiogram as guide, chosen cycling. Data obtained positive clinical cultures used preparing antibiogram. Results: general most prevalent species remained stable or showed minor sensitivity. While piperacillin/tazobactam failed statistical significance, indicated 4% with shift left minimum inhibitory concentration (MIC). Conclusions: controversial idea, yet it be successful technique achieve either stability continuous decrease antibiotic. Additionally, meaningful outcomes, selected length must accordance